Assessment of glial cells Evaluation of glial cells, such as microglia and astrocytes, was determined by performing Iba-1 and GFAP immunofluorescence, respectively. Add it to your IMDbPage. Molecular regulation of adult CNS neurogenesis: The mTORC1 is the primary target of inhibition by the drug rapamycin, but higher concentration of rapamycin or chronic treatment can also interfere on mTORC2 regulation [ 15 ]. Competing interests The authors declare that they have no competing interests. Upload Login Register Best videos Best galleries. Anti-inflammatory IL is upregulated in both hemispheres after experimental ischemic stroke:
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Forty-eight hours after QA administration, rotarod test was performed to evaluate motor coordination and balance. Horny Gay Teen Jerks On! How Much Have You Seen? Antonio Carlos Pinheiro de Oliveira, Phone: Making a connection with this member will use 1 StarNow Credit. Finally, this result, together with the data of the cytokines, suggests that microglia activation and neuroinflammation does not seem to mediate the neuroprotective effects of rapamycin in this model. Access 's of amazing talent not shown in the Talent Directory:
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Assessment of glial cells Evaluation of glial cells, such as microglia and astrocytes, was determined by performing Iba-1 and GFAP immunofluorescence, respectively. Detention Double-Dicking Cotton Candi. Blue wig crossdresser blowing. Known For Mike in Brazil Actress. Considering the important physiological role of these immune cells in glutamate homeostasis, a reduction in their number would lead to a lower reuptake of this neurotransmitter. The behavioral and biochemical assessments were performed as shown in Additional file 1:
Conclusions In conclusion, we demonstrated that mTOR inhibition with rapamycin reduced the motor impairment and neurodegeneration in an animal model of excitotoxicity, providing evidence of the involvement of mTOR in excitotoxic events. Other important cells from the central nervous system that are also involved in neurodegenerative processes are the astrocytes [ 56 ]. You must be logged in to use this feature. We first demonstrated that rapamycin prevented the motor impairment induced by QA. Discussion In the present study, we evaluated the effect of rapamycin in the excitotoxicity induced by intrastriatal injection of QA.